Comparative Effectiveness of Hybrid Closed-Loop Automated Insulin Delivery Systems Among Patients with Type 1 Diabetes
This retrospective clinical study compared outcomes of patients with type 1 diabetes using different hybrid closed-loop (HCL) systems in a real-world setting. The study included patients from an academic endocrinology practice who were new to any HCL system between January 1, 2018, and November 18, 2022. The outcomes assessed were the percentage of time spent in the target glucose range (TIR), percentage of time spent below the target range (TBR), and changes in HbA1c levels. Results showed that there were significant reductions in HbA1c levels with Tandem Control IQ (CIQ) and Omnipod 5 (OP5), but not with Medtronic 670G/770G (MT). TIR was similar across all three systems, but TBR was highest with MT. In conclusion, while all HCL systems showed improvements in certain outcomes, there were differences in TBR, with MT having the highest rates. The differences in the percentage of time in automated delivery likely explain variations in HbA1c changes but not in TBR between HCL systems.